By Shigeyuki Matsui,Marc Buyse,Richard Simon
Design and research of scientific Trials for Predictive Medicine presents statistical suggestions on undertaking medical trials for predictive medication. It covers statistical subject matters appropriate to the most scientific study levels for constructing molecular diagnostics and therapeutics—from deciding upon molecular biomarkers utilizing DNA microarrays to confirming their scientific application in randomized medical trials.
The origin of recent medical trials used to be laid a long time earlier than sleek advancements in biotechnology and genomics. Drug improvement in lots of illnesses is now transferring to molecularly certain therapy. faced with this kind of significant holiday within the evolution towards customized or predictive medication, the methodologies for layout and research of scientific trials is now evolving.
This publication is among the first makes an attempt to give a contribution to this evolution through laying a beginning for using acceptable statistical designs and techniques in destiny medical trials for predictive drugs. it's a resource for scientific biostatisticians, researchers targeting predictive medication, medical investigators, translational scientists, and graduate biostatistics scholars.
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Extra resources for Design and Analysis of Clinical Trials for Predictive Medicine (Chapman & Hall/CRC Biostatistics Series)
Design and Analysis of Clinical Trials for Predictive Medicine (Chapman & Hall/CRC Biostatistics Series) by Shigeyuki Matsui,Marc Buyse,Richard Simon