Antibody-Drug Conjugates: The 21st Century Magic Bullets for - download pdf or read online

By Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro

ISBN-10: 3319130803

ISBN-13: 9783319130804

ISBN-10: 3319376691

ISBN-13: 9783319376691

This authoritative quantity offers a holistic photograph of antibody-drug conjugates (ADCs). Fourteen finished chapters are divided into six sections together with an advent to ADCs, the ADC build, improvement matters, panorama, IP and pharmacoeconomics, case reports, and the way forward for the sector. The booklet examines every little thing from the choice of the antibody, the drug, and the linker to a dialogue of developmental matters akin to formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory demanding situations. It additionally explores pharmacoecomonics and highbrow homes, together with lately issued patents and the associated fee research of drug treatment. Case experiences are awarded for the 3 ADCs that experience got FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), in addition to an ADC in late-stage medical trials, glembatumumab vedotin (CDX-011). eventually, the amount provides a point of view via the editors at the destiny instructions of ADC improvement and medical purposes. Antibody-Drug Conjugates is a pragmatic and systematic source for scientists, professors, and scholars drawn to increasing their wisdom of state-of-the-art study during this interesting field.

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Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series) by Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro


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