Adaptive Design Theory and Implementation Using SAS and R by Mark Chang PDF

By Mark Chang

ISBN-10: 1584889624

ISBN-13: 9781584889625

Adaptive layout has turn into a major device in glossy pharmaceutical learn and improvement. in comparison to a vintage trial layout with static good points, an adaptive layout makes it possible for the amendment of the features of ongoing trials in line with cumulative details. Adaptive designs bring up the chance of luck, lessen expenditures and the time to industry, and advertise exact drug supply to sufferers.
Reflecting the cutting-edge in adaptive layout ways, Adaptive layout conception and Implementation utilizing SAS and R presents a concise, unified presentation of adaptive layout theories, makes use of SAS and R for the layout and simulation of adaptive trials, and illustrates how one can grasp diversified adaptive designs via real-world examples. The ebook specializes in basic two-stage adaptive designs with pattern measurement re-estimation prior to relocating directly to discover more difficult designs and matters that come with drop-loser, adaptive dose-funding, biomarker-adaptive, multiple-endpoint adaptive, response-adaptive randomization, and Bayesian adaptive designs. in lots of of the chapters, the writer compares tools and offers sensible examples of the designs, together with these utilized in oncology, cardiovascular, and irritation trials.
Equipped with the information of adaptive layout offered during this ebook, it is possible for you to to enhance the potency of your trial layout, thereby lowering the time and value of drug development.

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Adaptive Design Theory and Implementation Using SAS and R (Chapman & Hall/CRC Biostatistics Series) by Mark Chang

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