By Mark Chang
Reflecting the cutting-edge in adaptive layout ways, Adaptive layout conception and Implementation utilizing SAS and R presents a concise, unified presentation of adaptive layout theories, makes use of SAS and R for the layout and simulation of adaptive trials, and illustrates how one can grasp diversified adaptive designs via real-world examples. The ebook specializes in basic two-stage adaptive designs with pattern measurement re-estimation prior to relocating directly to discover more difficult designs and matters that come with drop-loser, adaptive dose-funding, biomarker-adaptive, multiple-endpoint adaptive, response-adaptive randomization, and Bayesian adaptive designs. in lots of of the chapters, the writer compares tools and offers sensible examples of the designs, together with these utilized in oncology, cardiovascular, and irritation trials.
Equipped with the information of adaptive layout offered during this ebook, it is possible for you to to enhance the potency of your trial layout, thereby lowering the time and value of drug development.
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Extra resources for Adaptive Design Theory and Implementation Using SAS and R (Chapman & Hall/CRC Biostatistics Series)
Adaptive Design Theory and Implementation Using SAS and R (Chapman & Hall/CRC Biostatistics Series) by Mark Chang